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Veterinarian Congress 2002, Zlatibor, Serbia, September 10th 2002.

ABSTRACT

The aim of this study is to show the possibilities of treating diseases of the blood vessels, skeletal articular system and connective tissue through the application of a permanent Magnetic Deep Unipolar Oriented Field (MADU) on reflexogenic zones (RZ) and smaller areas or reflexogenic (acupuncture) points (RP). The MADU strip was patented by MD. PhD. Dusanka Mandic under No. PCT/YU 98/00018, WO 99/60581 as a technically new non-invasive solution for prevention and therapy both checked and assessed by the World International Property Organization (WIPO)
Method: The council of medical doctors of various specializations treated outpatients with diseases of the arteries, and degenerative diseases of the hip and knee joint. Permanent magnets were applied with a power 10 to 15 times weaker than tested and approved levels prescribed by the World Health Organization (WHO). The power of the magnetic fields was measured by a magnetometer [Gaussmeter RFL, Zurich, Switzerland (precision: 10 Gauss to 10 kilogauss)], while the reactive distance and depth of their influence was measured by a proton magnetometer [Portable Proton Magnetometer Model G-856A, EG&G, Geometrics, USA (precision: 50 nanoTesla)]. One or more magnets, in the form of a strip, was placed on the surface of the body (RZ) and focused like a magnetophore (RP), with the north face turned towards the skin [North (N) pole or Negative pole (-)]. The strips were adhered by means of plaster, bandage or pieces of cloth. The magnetic strips and magnetophores retained contact with the body for a period ranging from 24 hours to one year according to the patients’ needs, determined according to their clinical data. The effectiveness of therapy for vascular diseases was evaluated on the basis of the clinical data, measurements (in mm) of the vascular gangrenous defects during the period of healing and the blood vessels’ Color Doppler ultrasonographic findings. The effectiveness of therapy for the degenerative musculo skeletal diseases was evaluated according to the score which was achieved through a diagnostic test questionnaire, containing a section concerning subjective difficulties and assessment of disabilities, assessment of radiological findings and the objective measurement of mobility. The author of this questionnaire is Prof. dr. sc med. Ivan Butkovic
Results: In patients where amputation of the leg was indicated due to gangrenous disease, the leg was saved in 30% of cases and in follow up examinations the status of regeneration was confirmed. Within the group of patients with degenerative skeletal articular diseases, improved condition was confirmed on the basis of the radiological findings of regeneration and was found in 67% of the controlled patients. During 12 months of therapy, according to follow-up examinations, the condition in 20% of the patients remained the same and in 13% of the patients the disease progressed. The duration of treatment ranged from five months to two and a half years, with an average duration of 1.4 years.
Conclusion: When applied for extended periods of time in the form of magnetic strips and magnetophores, MADU makes possible a regenerative process of the bone cartilage and soft tissues, as a result of their influence on vascular, metabolic and enzymic processes. Their regenerative processes can be so successful that, besides qualitative renewal of the structure of the

1 Mandić Dušanka, MD. PhD., occupational health specialist, Specialised practice “MADU”, Beograd, Gostivarska 56A
2 Đorđević Drago, mr sc. med., physical medicine and rehabilitation specialist , Institute of patho physiology, Medical Faculty, Beograd, Dr Subotića 9
3 Cvetković Dragan, medical doctor specialising in surgery, Pacemaker Centre, Institute for cardiovascular diseases, Clinical Centre of Serbia ,Beograd, Višegradska 26
4 Strugarević Evgenija, medical doctor, Specialised practice “MADU”, Beograd, Gostivarska 56A
bone tissue, it can lead to the formation of new joint space, which creates a better and more efficacious function of the joint, with a better quality of life.

INTRODUCTION
During the last century, technical achievements in medicine provided new and great possibilities in diagnostics and therapy, as we are witnesses of a new technical age in medicine.
One of the contemporary novelties in medicine, based on ancient techniques of the application of natural magnetism – a practice more than a thousand years old, is the new technology in therapy which includes the application of the MADU magnetic deep unipolar oriented field / Mandic, D, Patent PTC .Yu 98/00018, WO 99/60581 Surface Magnetized Elastic Magnetic Strip and Application, P- 214/ 98, number 48907 from August 19th 2002.
The MADU strip, applied as a medical device, has been awarded an internationally protected patent in 98 countries (PTC). It has also been declared a Novelty (N), Inventive Step and Industrial Applicability (IA) as per the research and subsequent assessment of the WIPO (World Intellectual Property Organization)
A magnetic field oriented in this manner, being a type of energy similar to the biophysical mechanism of living beings, causes principal changes in an organism. The success of the therapy is interpreted and explained according to what is known to-date of the pathophysiological performance mechanism. The following is observed: dipoles are put in order, there is vasodilatation, liquid viscosity improvement, a spazmolitic effect, increase in temperature and increase of the metabolic processes in the exposed tissue, wound healing is accelerated, there is faster haematoma resorption, and improvement and acceleration of the regeneration process in various tissues.

THE AIM
The aim of this work is to present the new possibilities and efficacy of non-invasive therapy on living beings by applying the influence of a magnetic deep unipolar oriented field (MADU) on damaged tissues.

METHOD AND MEANS
Permanent magnets were used (Ba ferrite and rear earth) with an intensity 10 to 15 times lower than the levels examined and approved by the World Health Organization / Magnetic fields WHO 1987, Environmental Health Criteria 69, p.20, 127-144 ISBN 92-4 154269 1, ISSN O250-863X. /.
The measurement of magnetic field intensity was performed using a magnetometer in Gauss or MT [Gaussmeter RFL, Zurich, Switzerland (accuracy: from 10 Gauss to 10 kiloGauss)]. Measurement of the reactive distance, or the depth of activity, was performed using a proton magnetometer, and the achieved depth ranged from 1.5 to 55 cm. [Portable proton Magnetometer Model G-856A, EG&G, Geometric, USA (accuracy: 50 nT- nanoTesla)], depending on the model of the strip.
General and local effects were observed and interpreted.
Outpatients with diseases of the arteries who had been previously treated many times by standard medical procedures were treated during a period of 4 to 20 months or for even more years. The total number of patient is 72, 21 patients with angiopathia diabetica (21,16%) (MKB-10 179.2-179.8 (E 10- E 14 )), and 51 patients with Stenosis of the blood vessels ( 70.83%) (MKB -10- 170-179, 173.0 - 173,9,177.1,) International classification of diseases, 10th revised edition, 1996., ISBN 86-311-0307-1.
The second group of patients included patients of both gender suffering from degenerative skeletal and articular system diseases such as osteoporosis and systematic rheumatoid diseases. Statistical evaluation was performed on 257 patients. The dominant diagnosis was Coxarthrosis (MKB -10, M-16 page 558), and Gonarthrosis (MKB-10, M-17, page 559). These joints, being the biggest in the human body, usually restricted the ability to function, so the results achieved during therapy were obvious.
The invention, protected by patent, was used and one or more MADU strips was applied on the surface of the body, with the North Pole facing the skin and adhered by adhesive strip, bandage or strips of cloth. Before placement of the MADU strips, MADU methodology for dipole arrangement is performed during a period of 30 to 120 minutes. The patients wore the magnetic strips for 24 hours during a period of days, months or years, depending on the need of the patients determined by their clinical status or achieved degree of improvement. It was permitted to remove the magnetic strips only when bathing. After the placement of magnetic strips, all patients were supplied with instructions for their use.
The patients with vascular diseases who were treated were permitted to remove the strips for three days, after having continually worn the strips for three weeks. After the three days, the strips were reapplied on the same area or at some other location according to the clinical findings. The follow-up examination was performed according to the patients’ specific needs during an interval from one to six weeks, depending on assessed need. If the follow-up intervals were longer than 21 days, the patients were contacted by phone concerning their health status, also additional information was given to patients according to their needs.
Patients suffering from diseases of the skeletal articular system wore the MADU strips continually for a longer period, not less than six months, and some patients wore the strips for four years. Treatment before the placement of the MADU strips and in the follow-up examination was performed according to the MADU methodology for dipole arrangement.
The council, consisting of specialists for orthopedic surgery and traumatology and a specialist of physiatry and rehabilitation, performed examinations of the patients suffering from skeletal and articular system diseases. For the treatment of those patients suffering from other diseases, appropriate specialists were called in according to the specific need.
The treatment of animals is performed in cooperation with doctors of veterinarian medicine.

RESULTS
Altogether, 72 patients diagnosed with diseases of the arteries were treated. Before the treatment all patients had increased difficulties lasting from 3 months to 44 years (average 10.36 years) and all had been treated with usual medical procedures as outpatients or inpatients (hospitalized). The average age of patients ranged from 32 to 82 years.


TABLE 1
Results of MADU strips’ application in 1999 and 2000 (No72)

PACIJENTI
  MALE FEMALE SANATED/IMPROVED TOTAL
  NUMBER % NUMBER % NUMBER %   NUMBER %
DIABETC FOOT WITH GANGRENE 10 47,62 11 52,38 7 30,00 21 100,00
STENOSIS of ARTERIES (VARIOUS & VARIOUS LOCATIONS)
39 76,47 12 23,53 38 74,51 51 100,00
TOTAL 49 68,05 23 31,94 45 62,50 72 100,00

 

During follow-up examinations, attention was paid to indicators of the status of the skin and nails, the pulsation of the extremitas’ arteries, edema presence, skin temperature, skin color and the follow-up ultrasonogaphic examination of the pass ability of blood vessels.

The most frequent diagnosis of the treated patients is:
*Occlusio a. femoralis superfitialis dex. Occlusio a. popliteae dex. hypertensio arterialis. Hyperlipidaemia. Diabetes mellitus.
*Angina pectoris. Diabetes mellitus. type II. Dislipoproteinemia II a.
*Embolio art. fem.l. sin. Embolectomia facta est am I. Diabetes mellitus. type II Angiopathia diabetica. Dyslipoproteinemia.
*Angina pectoris. Diabetes mellitus. typ II. Dislipoproteinemia II a.Hypertensio arterialis.
*Gangrena sicca digitorum pedis l.sin. 785.4, Mb.Leriche.Occlusio aa. femoralis superficialis bill.St. post thrombectomiam et patch plasticam cum Dacron patch a. illiacae ext. a. femoralis comm. et a. profundae femoris l.sin. a. a. II Hypertensio art.
*Obliteratio iliofemoralis l. dex.
*Phlebitis migrans cruris.St. post extirpationem VMS bill. factam a.m. II.Obliteratio aa. crurum utr.Vasculitis susp.
*Thrombangitis obliterans Buergeri
*Stenosis a. carotis internae bill (desno 75%, levo 85%)
*Stenosis a femoralis superfitialis.l.sin.gradus med.Occlusio a. tibio-peronealis.l.sin.Occlusio a.femoralis superfitialis.l.dex.

In patients suffering from Diabetes mellitus together with gangrenous changes, improvement was achieved in 7 cases, or 30% of the total number of 21 patients with the same diagnosis. The group had 10 (47.62%) male and 11 (52.38%) female patients. The blood sugar level ranged from 3 m mol/l to 28 m mol/l with an average value of Med= 15,6 m mol/l and mode value Mod= 15 m mol/l. The average level of cholesterol in those patients was 7.58 m mol/l. As
an accompanying difficulty, 19.35% of patients had arterial hypertension. Before using the MADU method, 41.93% of patients had one or more therapy series in a hyper baric chamber. The patients suffering from Diabetes mellitus together with gangrenous changes had already been treated at various clinics and had shown indications for the need of finger or limb amputation, and came for therapy after having refused the radical method (amputation). Due to the same disease, 6 patients were treated who had already had one leg amputated and who refused amputation of the other leg.
The total number of patients with various stenoses of arteries in different locations was 51 (70.83%), 38 male (74.51%) and 13 female (25.49%). Among those patients, 35 (68.62%) of the total number of 51 - thus the majority - were patients with “smoker’s leg”, having smoked tobacco from 6 to 40 years. The total number of tobacco smokers was 64.52%, of which 19.35% had stopped smoking.
Patients felt the earliest improvement even during the first procedure and at last had a good night’s sleep. The patients were treated using MADU strips alongside standard therapy for a period of approximately 21.75 months, or 1 year and 9.75 months. This period is probably not definitive, because after establishing the stable status of vascularisation it is necessary to keep the status of oxygenation at the highest possible level.
The second group of patients suffers from diseases of the skeletal and articular system. Statistically, 257 patients were examined with the most frequent diagnosis of Coxarthrosis.
In 67% of the total number of observed patients, improvement of the status of the treated skeletal and articular region was achieved, in 20% of the patients the stopping of the pathological process occurred – even though by its nature it is always progressive, and in 13% of the patients the pathological process progressed and led to the destruction of bone structures as if therapy had not been applied.


TABLE 1.- Patients treated with hip arthrosis according to the average number of achieved points at single examinations

Statistic parameters:
nUMBER of treatments
one two Three four five six
Number of patients 257 98 30 9 2 2
Minimal number of points 26 31 47 62 67 53
Maximal number of points 100 95 89 89 75 76
Average number of points 60.86 67.96 74.80 78.11 71 64.50
STANDARD DEVIJAtion 12.93 13.70

11.38

7.96 5.66 16.26
Variation coefficient in % 21.22 20.15 15.21 10.19 7.97 25.21

 

Patients treated of hip arthrosis (n =98) according to the number of points achieved at the first examination and follow up examination
Interval of reliability for the probability of p=0.95

KEY: granica = border, gornja =upper, donja=lower, prosek= average, I pregled=1st examination,II pregled 2nd examination

 


Patients treated of hip arthrosis (n=30) according to the number of points achieved at the first, second and third examination
Interval of reliability for the probability of p=0.95

KEY: granica = border, gornja =upper, donja=lower, prosek= average, I pregled=1st examination,II pregled= 2nd examination, III pregled = 3rd examination


The following of the results was performed according to the number of gained points (from the maximum 100) at the first and following follow-up examinations during 1.5 to 2 years. (Table I.)
Patients gained at the first follow-up examination an average 60.89 points (the minimum number of points was 26 and maximum was 100). At the second follow-up examination patients gained an average 68.09 points (minimum 31 points and maximum 95 points), and at the third follow-up examination patients gained an average 75.41 points (minimum 47 points and maximum 89 points).
The increase in the number of points shows the increase in the quality of life of the treated patients. The questionnaire was formed with a maximum of 100 points so the increase of the quality of life could be presented in points.
Testing the hypothesis of the relation between the first and third follow up examinations for the interval of reliability for the probability P= 0.95 it is significantly higher, p<0.001.

DISCUSSION
The positive effect of MADU strip application in the treatment of the patients is based on several different mechanisms of performance, Tenforde T. S. (1992); Frankel R.B., Liburdy R. P.(1995) starting with the modulation of the potential of NA /K pump through the cells’ membranes, Sadafi H. (1998) through the synchronization with endogen oscillations of Ca++ ions in the rhythm of geomagnetic activity, Berridge M.J., Galione A. (1988); Berridge M.J., Bootman M.D. (1998) to the conformation changes of the water molecules.
One of the most famous and earliest discovered mechanisms of permanent magnetic field activity is the analgesic and antinflamation effect which fundamentally improves tissue vascularisation caused by increased blood circulation and metabolic functions. Lawrence R., Rosch P.J., Plowden J. (1998); Kniazeva T.A., Otto M.P., Markarov G.S., Donova O.M., Markarova I.S. (1994). Circulation improves in the magnetic field because of the spasmolitic function associated with the improvement of blood viscosity Gorczynska E. (1988); Lud G.V. (1986), as well as oxygenation not only in tissues, Tiller W.A. (1997) but also in erythrocytes Traikov L. (1996).
Closer mechanism effects are related to the magnetic characteristics of substances exposed to the action of the unipolar oriented magnetic field causing an adequate response in relation to the force lines and vector direction. It is scientifically confirmed that in the magnetic field the dipoles and ions are arranged regularly like palisades, with the positive pole oriented towards the negative pole of the magnet. Baermann H.M. (2000). The separation of the particles charged with electricity is proportional to the field’s power, speed of the particles’ movement and angle between the direction of electricity and magnetic field’s vector. Zablotsky T.J. (2000) An important effect of the negative pole action also represents a neutralisation of the pH of tissue liquid with dominant alcalization, Tiller W.A. (1997) which improves many of the enzymes’ activities, especially that of metallic enzymes - which represent one third of the total number of all the enzymes in an organism. The great influence in the behavior of liquid exposed to a magnetic field can be observed in water, which not only changes its conformation cluster structure but also the crystallization form of diluted calcium carbonate, Kmecl P., Jerman I., Škarja M. (2000) which is probably true for other dilluted substances.
The grateast contribution to antiinflamatory, spasmolytic and antithrombotic effects of the magnetic field is the inhibitory effect on the production of cytokines, interleukine 1 [interleukine 1 (IL-1)] and tumor necrosis factor [tumor necrosis factor (TNF)] from many cells, Ryaby J.T. (1996); Lo Casto ... (2000), especially epithelial and macrophages. Mehta S. (1996) Suppression of these proinflamatory cytokines accompanies the additional increase of interleukine 2 secretion [interleukine 2 (IL-2)] from the normal human T- lymphocytes. Mehta S. (1996). The IL-2 increase is important because IL-2 regulatory cytokine, which has effects on the growth of human T lymphocytes and B lymphocytes, also stimulates the natural defense mechanism through natural killer cells [NK (natural killer) cells].
Activated endothelial cells can produce cytokines, such as IL-1 or TNF, Terr A.I. (1994) although they may be of extra vascular origin. Ridker P.M., Genest J., Libby P. (2001) IL-2 and TNF in blood vessel endothelium cause many changes, starting from permeability increase and structural cell reorganization,approaching and molecule adhesion on them. Libby P. (2001), Libby P. (2001) .
The increase of metabolic activity achieved by the action of the magnetic field is improved by the phagocyte ability of macrophages and microphages, Kubota H., Nishimura I., Negishi T. (2000) as well as the production of NO from them, a very potent vasodilatator.
Uninjured endothelium cells, which normally secrete antitrombocyte factors, prostacycline (PGL2) and NO that prevent trombocyte adherence and aggregation, Mitchell R.N., Cotran R.S. (1999) increase their metabolism under the influence of the magnetic field, intensifying their production of these substances. NO manifests its vasodilatation effects in the increase of the production of the intracellular inhibitor (IkBa) expressing the gene transcriptional regulator of the nuclear factor - kappa B [nuclear factor kappa B (NK?B)].Libby P. (2001). The NK?B system generally regulates many genes included in the inflamatory responses, particulary in aterogenesis, Peng H.B., Libby P., Liao J.K. (1995). Besides, released NO secretes into postsynaptic space and connects to the iron chem-group of the soluble enzyme guanylyl cyclase, activating itself and acting on guanosine triphoshate [guanosine triphosphate (GTP)], increasing production of cyclic guanosine monophosphate [cyclic guanosine monophosphate (cGMP)], through which the effect of NO is achieved. Iron is a powerful ferromagnetic element on which the magnetic field has a fundamental influence, whereby NO production is increased and vasodilatation and antitrombocyte effects are strengthened.
Tissue metabolism improvement also improves the enzyme activity of the cells, especially the catabolic activity of metal proteinasis that decelerates and stops the synthesis of extra cellular matrix and stops accumulation on the arteries’ walls. Thus conditions for the stop of the pathological processes are created, as well as for the easier removal of ateromatose changes, which together with vasodilatation causes improvement of tissue perfusion.
The suppression of the production of IL/1 influenced by a magnetic field decreases its action to selectively damage pancreas b cells and causes changes in the insulin level in plasma.Oppenheim J.J., Ruscetti F.W., Faltynek C. (1994) It additionally improves tissue metabolism, especially in persons with insulin secretion disturbances and resultant weak glucosis regulation.
Damaged nerve fibers are then renewed and innervations are established in the affected area, as confirmed by vitro researches. Herbst E., Resig P., Ranney S., Sisken B.F. (2000); Sisken B.F., Midkiff P., Twehues A., Trumbo R. (2000) In that way, through the action of the magnetic field, all conditions are established for better regeneration of the damaged tissue, achieved by better vascularisation and oxygenation, Gmitrov J., Ohkubo C. (1999) faster connective tissue maturation, reduction of fibrous, scar tissue, Detlavs I. (1996) and epithelization improvement, which leads to complete wound healing. Semrov D. (1996)
Besides these mechanisms, regenerative processes on the skeletal and articular system refer to the following:

Modulation potential of the K/Na pumps through cell membranes Sadafi H. (1998) through synchronization with endogen oscillations of Ca ++ ions in the rhythm of geomagnetic activity, Berridge M.J., Galione A. (1988); Berridge M.J., Bootman M.D. (1998) then to the conformation changes of water molecules, Olarsch G. (1999) like antennas.

Regenerative processes can be so successful that besides qualitative renewal of the bone structure and pain removal it can lead to disappearance of sclerosed joint fissures and the formation of a new one, leading to improvement or the return of articulation functions.
In the cartilage tissue of the articulation synovial liquid it is possible for the action of the magnetic field to have extreme positive effects on the water molecules and bio molecules. The basic content of cartilage matrix in terms of water and biomolecules are proteoglicanes of articular cartilage, macromolecules of a basic substance, which consists of glicosamineglicane (chialuronate, chondroine sulpahate, and keratin sulphate) Voet D. Voet J.G. (1995) and proteins connected by covalent and non-covalent connections to a big negative electricity charge, also responsible for the large amount of BONDED WATER. Krane S. M., Neer R. M. Hyaluronic acid as a main axial glicosamine glicane is the most responsible for the polianion characteristics, because its lateral remains has an anion nature, so it tightly connects to cations such as Na+, K+, and Ca++. Those structural characteristics, with a big molecule mass and numerous anion groups, give to every chialouronate a large volume and specific hardness. The big volume and accompanying chialouronate rigidity are particularly important if we consider that one hydratated molecule occupies a space 1000 times bigger than a molecule in dehydrated, dry state. Voet D., Voet J.G. 1995. In cartilage tissue 65 - 80 % of the weight consists of water.
For the regeneration of chialine cartilage, the optimum Ph is 7.6. The cell membrane is charged with negative electricity and positive ions are moved through the cell membrane which is important for potential dependent chanels (volt depending) and the existing ligand dependant chanels or receptor chanels.

METHAPLASION FROM THE CONNECTIVE TISSUE
The bioelectric conception of the regulation function of connective tissue in bones, cartilage and tendons, and other tissues exposed to the action of mechanic powers, is based on the biological hypothesis of the function of natural biomolecules in the extracellular matrix like that of biosensores and conductors, which have similar conduction to the nerves. Regling G. (2000). According to this hypothesis, the net of the collagen fibres represent a universal bioelectric and/or signal system of bioelectromagnetic energy composed of charged biomolecules of collagen fibres functioning on the level of an electrical potential much smaller than those with current effects, which provides a biological perception of the stimulus and signal conduction. Djordjevic D. , Mandic D. (2001)

CONCLUSION
ACHIEVED RESULTS, INTERPRETED AND AFFIRMED USING UP-TO-DATE WELL-KNOWN PATHO PHYSIOLOGICAL MECHANISMS, SHOW THAT IN THE FRAME OF PREVIOUSLY MENTIONED DISEASES TREATMENTS, THE USE OF MAGNETIC DEEP UNIPOLAR ORIENTED FIELD (MADU) CAN BE ADDED - AND JUSTIFIED. THANKS TO ITS PRINCIPAL ACTIVITY, THE USE OF THIS PHYSICAL FIELD OPENS NEW POSSIBILITIES IN PROVIDING EFFICACIOUS HEALTH PROTECTION AND BETTER LIFE'S QUALITY ACHIEVMENT

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